This is consistent with the suppression of soft-agar colony and sphere formation in ZDHHC17-expressing glioma cells upon pharmacological inhibition of JNK1/2 (p38) or JNK-IN-8 (PH-797804) Moreover, JNK1/2 (anisomycin) or p38 (P79350) activation partly rescued the ZDHHC17 knockdown-mediated migration, invasion, and foci formation down-regulation. Here, MAPK1 is linked to central nervous system cancer.