To assess the link between ZDHHC17-MAP2K4 signaling module and GBM tumorigenesis, ZDHHC17-expressing and -deficient GSCs derived from luciferase-expressing U118MG cells were implanted into the brains of immunocompromised NOD/SCID mice (Figures 7G and 7H). Here, ZDHHC17 is linked to glioblastoma.