ABCB1 and hepatocellular carcinoma: Pascal et al. developed a mathematical model that evaluated the delivery of nano-formulated doxorubicin to hepatocellular carcinoma tumor cells, and concluded that improved efficacy achieved by TNP could largely be attributed to enhanced cellular uptake rates of TNP compared to solvent-based formulations, particularly in cancer cells overexpressing the drug efflux pump P-glycoprotein (MDR1) 145.