Furthermore, the expression of CDX2 was diminished in human breast cancer epithelial cell lines MCF-7 and MDA-MB-231 compared to that of normal human breast epithelial cell line HBL-100, where the MCF-7 cell line exhibited the lowest expression of CDX2 (p < 0.05; Fig. 1f). The gene discussed is CDX2; the disease is breast carcinoma.