Meanwhile, in cells treated with both let-7b inhibitor and CDX2 over-expression, EdU positive-cells were reduced, cancer cells migration and invasion were restrained, E-cadherin and CDX2 protein expression was increased and Vimentin protein expression was decreased relative to NC of let-7b inhibitor and over-expressed CDX2 (p < 0.05). The gene discussed is VIM; the disease is cancer.