In addition, in the experiment of tumor xenografts, it was displayed that in comparisons with B16 group, the tumor volume was substantially elevated in B16-lncRNA MEG3-siRNA group, but the tumor volume in A2058 or A375 group was notably lighter than that in A2058-lncRNA MEG3 or A375-lncRNA MEG3 group, respectively (Fig. 3b). This evidence concerns the gene MEG3 and neoplasm.