SPHK1 and Familial prostate cancer: For instance, lncRNA MEG3 inhibits the progression of prostate cancer by modulating miR-9-5p/QKI-5 axis [16]; Down regulation of lncRNA MEG3 promotes colorectal adenocarcinoma cell proliferation and inhibits the apoptosis by up-regulating TGF-β1 and its downstream sphingosine kinase 1 (SPHK1) [17]; lncRNA MEG3 suppresses the tumorigenesis of hemangioma by sponging miR-494 and regulating PTEN/PI3K/AKT pathway [18].