MEG3 and neoplasm: For example, lncRNA DLX6-AS1 promotes liver cancer by increasing the expression of WEE1 via targeting miR-424-5p [12]; lncRNA MORT overexpression inhibits cancer cell proliferation in oral squamous cell carcinoma by downregulating ROCK1 [13]; lncRNAGIHCG induces cancer progression and chemoresistance and indicates poor prognosis in colorectal cancer [14].It has been found that lncRNA maternally expressed gene 3 (MEG3) with tumor suppressor activity was frequently either lost, mutated or decreased level in many human tumors and tumor derived cell lines [15].