We chose B16 (mouse cell line) and A2058/A375 (human cell line) not to compare the difference between mouse cell line and human cell line, but only because lncRNA MEG3 was highly expressed in mouse cell lines and low in human cell lines, and we wanted to investigate the biological role of high and low expression of lncRNA in melanoma cells, regardless of cell lineage differences. The gene discussed is MEG3; the disease is melanoma.