CHKA and cancer: The inhibition of lipid biosynthesis observed with AZD3965 in the Raji model may in fact contribute to the anti-proliferative effects of the drug observed in our study given the role of lipogenesis in promoting cancer cell growth and proliferation.25,26 However, the mechanism underlying the link between lactate accumulation and decline in lipid biosynthetic enzyme expression, particularly CHKA, is unclear.