However, in human studies, effects of vitamin D supplementation on insulin sensitivity are not consistent; beneficial in healthy Japanese (12 month study)31 and centrally obese Asian Indian (8 weeks study)32, but not seen in elderly overweight Lebanese (12 month study)33 populations or in our current study (HOMA_IR)on women with prediabetes with longer duration of follow up. The gene discussed is INS; the disease is prediabetes syndrome.