ACHE and cognitive disorder: Based on PASS prediction results, we also selected the plant (Physostigma venenosum) with four phytomolecules (eseridine, physostigmine, physovenine, and eseramine) for which dual MOAs (inhibition of acetylcholinesterase and butyrylcholinesterase) and pharmacological effects related to the treatment of VaD (cognition disorder treatment and nootropic) were predicted with a probability Pa of more than 0.5 (Table S8).