To display it we made such analysis for 3 new VaD-related targets from Table 2 (Glycogen synthase kinase-3 alpha; Protein phosphatase 1B and Bradykinin B2 receptor) and two targets with known associations to vascular dementia, which are not used for the treatment of vascular dementia at the present time, from Table 1 (Indoleamine 2,3-dioxygenase and 5-hydroxytryptamine receptor 1A) based on information about directed interactions between proteins from SIGNOR 2.0 database23. The gene discussed is PPM1B; the disease is vascular dementia.