ALK and neuroblastoma: In line with our findings, Eleveld et al. 31 recently established a 6-gene core RAS/MAPK pathway signature in neuroblastoma that includes ETV5. We also confirmed that the remaining genes, ETV1, ETV4, DUSP4 and DUSP6 display similar regulation as ETV5 upon the inhibition of MAPK, PI3K or ALK (Supplementary Fig. S2).