Next, we analysed the correlation between ETV5 levels and a RAS/MAPK activity score30 in a panel of 28 neuroblastoma cell lines and two independent cohorts of 283 and 498 primary neuroblastomas tumours (NRC and GSE49711 datasets, respectively), and found a significant positive correlation (p-values 0.0345, 1.147e-10 and 4.051e-9, respectively, Supplementary Fig. S1). This evidence concerns the gene ETV5 and neoplasm.