We found that following A-769662 treatment, co-localization of TnT with filamin-C (Fig. 6A,B) and caveolin-3 (Fig. 6C,D) in DCM iPSC-CMs was significantly increased, suggesting that AMPK activation supports recovery of both sarcomere-cytoskeleton- and sarcomere-PM attachment. This evidence concerns the gene FLNC and familial dilated cardiomyopathy.