The SNPs rs138980799 in IVL, rs191590289 in METTL20, rs140732889 in ZNF677, and rs4889261 and rs13339342 in PKDIL2 did not reach statistical significance with POAG from both replication cohort #1 (Korea) and cohort #2 (Japan). This evidence concerns the gene IVL and open-angle glaucoma.