Multiple genes have been reported to be associated with POAG at the genome-wide level, including CAV1/CAV2, ATOH7, TMCO1, CDC7-TGFBR3, MPP7, CDKN2B-AS1, and SIX1/SIX6, from various populations in Europe, the United States of America, India, Japan, and China12–20. This evidence concerns the gene CDKN2B and open-angle glaucoma.