Of the top 10 transcripts upregulated at peak HIV-1 viral load, the majority (6 out of 10) were related to cell cycle and cell division including RRM2, MYBL2, CDK1, UBE2C, CDC45, and TK1 with 8 to 15-fold increased expression compared to the pre-infection samples (Supplementary Table 4). Here, RRM2 is linked to infection.