BCL2 and cancer: To evaluate the proapoptotic effects of these conditioned media (CM) and/or their ability to enhance apoptotic pressure on specific antiapoptotic proteins, we added them to “recipient” cancer cells alone or in combination with distinct BH3 mimetics targeting either BCL-2 (ABT-199), BCL-xL (WEHI-539), or MCL-1 (S63845) prior evaluation of cell death rates.