STING1 and breast carcinoma: To corroborate that STING activation contributes to enhancement of apoptotic priming by paclitaxel treatment also in primary breast cancer cells, we used organoids derived either from PDX or from freshly excised human breast cancer specimen (Patient-Derived Organoids PDO) where synergistic effects on cell viability between paclitaxel and ABT-737 (but not ABT-199) were detected (Fig. 1j).