In addition, post-mortem studies have reported lower levels of dendritic spines14,15 and of protein and mRNA levels of a number of synaptic markers, including synaptic vesicle proteins such as synaptophysin and synaptopbrevin16–19, and postsynaptic markers such as PSD-9517,20, in schizophrenia. Here, SYP is linked to schizophrenia.