The exploratory analysis of additional brain regions showed significantly lower SV2A levels in the dorsolateral prefrontal and temporal cortices and occipital lobe in schizophrenia, consistent with other evidence implicating synaptic pathology in these regions in schizophrenia14,15,19,41,42, but not consistent with meta-analytic post-mortem findings for synaptophysin in these regions8. This evidence concerns the gene SYP and schizophrenia.