The response to JQ1 varied among these cells, whereby BLBC cells with low JunD/RSK3 levels were highly sensitive and lost almost 50–70% of cell viability, while luminal/HER2+ breast cancer cells with high intrinsic JunD/RSK3 level showed obvious resistance with only a 10–20% decrease of cell viability (Fig. 3e). Here, RPS6KA2 is linked to breast cancer.