RPS6KA2 and breast carcinoma: Interestingly, the expression level of miR-548d-3p was highly upregulated in BLBC cells which was confirmed by real-time PCR in an array of breast cancer cell lines (Supplementary Fig. 4F), and bioinformatics analysis of The Cancer Genome Atlas (TCGA) indicated that the expression of MIR548D1 is uniquely and robustly upregulated in the basal-like subtype compared with the other four breast cancer subtypes (Supplementary Fig. 4G), at least partially, explaining why JunD/RSK3 signalling is downregulated in BLBC cells.