IL10 and neoplasm: Principal-component analysis (PCA) of microbial community gene expression detected by both our de novo assembly and aligning the microbial transcriptome sequencing (RNA-seq) reads to the human gut microbiome integrated gene catalog (IGC) showed separate clustering of biofilm-positive CRC tumor tissue (BF+T) associated ApcMinΔ850/+;Il10−/− mice from biofilm-negative healthy patient tissue (BF-bx) associated mice (Fig. 1B and Fig. S2A in the supplemental material, respectively).