Although the depleted miRNAs in BF+T mice, miR-690 and miR-709, are not found in humans, they do share several CRC-related gene targets (such as Ctnnb1, Il6ra, Stat3, Src, and Zeb1) with other miRNAs depleted in CRC (17). The gene discussed is CTNNB1; the disease is colorectal carcinoma.