SST and Alzheimer disease: In contrast to many studies targeting dysfunctional excitatory synapses [46–49] or LTP induction-related intracellular cascades in order to restore LTP in Alzheimer’s disease mouse models [49–51], we show that reinstating SST interneuron-mediated disinhibition [39] is sufficient for restoring tLTP in AβO1–42-treated slices in vitro (Figs. 5 and 6).