Mechanistically, circ-HIPK3 enrichment can abundantly sponge miR-558 to decrease heparanase (HPSE), VEGF, and matrix metallopeptidase 9 (MMP9) levels, thus effectively suppressing the invasive abilities and angiogenesis of bladder cancer cells [85]. The gene discussed is HIPK3; the disease is urinary bladder carcinoma.