Another study concerning the role of ciRS-7 in ESCC demonstrated that ciRS-7 can prompt ESCC progression through miR-7/HOXB13/NF-κB or miR-7/KLF4/NF-κB axis, providing novel prognostic indicators and therapeutic targets for ESCC patients [51, 52]. The gene discussed is NFKB1; the disease is esophageal squamous cell carcinoma.