FOXO3 and neoplasm: According to histological analysis, the infiltration of B- and T cells into the tumours and surrounding connective tissues expressed circ-Foxo3, suggesting an immune response of the hosts to the tumour xenografts [105].Current data provided by Zou et al. showed that circ-CDR1as takes an important role in immune cell infiltration in tumour tissues, especially those of CD8+ T cells [75].