PDPK1 and non-small cell lung carcinoma: Recently, Zhou et al. reported that hsa_circ_0004015, a highly-expressed circRNA in NSCLC tissues, can act as a miR-1183 sponge to regulate 3-phosphoinositide dependent protein kinase 1 (PDPK1), thereby increasing the resistance of NSCLC cells to gefitinib [54].