TNF and neoplasm: It has previously been shown that Nr2f6−/− T cells are hyper-reactive in regard of cytokine production (IL-2, IFNγ, TNFα) as those cytokines are direct target genes of NR2F6-dependent transcriptional repression [25, 26, 28–30] leading to an improved anti-tumor immune contexture at the tumor site [29, 30].