MMP7 and metastatic malignant neoplasm in the lymph nodes: Tao Jiang et al. [44] showed that the number of circulating anti-matrix metalloproteinase 7 antibodies was elevated in patients with oral squamous cell carcinoma compared with that in normal controls and its higher levels were significantly correlated with lower histological differentiation, lymph node metastasis, late TNM stage and poor overall patient survival.