An example of this is an SLE risk variant that is also a cis-eQTL for the TF IKF1. The eQTL on IKF1 affected the transcription of 10 genes in trans that are all regulated by IKF1 [70], highlighting this gene as a likely candidate causal gene for SLE. The gene discussed is TF; the disease is systemic lupus erythematosus.