The NGS-based studies here reported did not always analyze univocal genes other than BRCA1 and BRCA2, but one could expect that further studies, focused on analysis of well selected patients/families and coupled to the improvement and standardization of bioinformatics investigations, will have a strong chance of identifying novel genes/variants involved in familial breast and ovarian cancers. The gene discussed is BRCA1; the disease is ovarian cancer.