ALS patients generally have less antecedent conditions (defined as conditions present prior to ALS onset) compared to age-matched controls [37,38]; nonetheless, a substantial portion of ALS patients are treated for antecedent conditions that are common in the age-matched general population, such as hyperlipidemia (e.g., with statins), hypothyroidism (e.g., with levothyroxine), hypertension (e.g., with calcium channel or beta blockers), and diabetes (e.g., with insulin replacements or blood sugar regulators like metformin). The gene discussed is INS; the disease is amyotrophic lateral sclerosis.