HNF1A and malignant colon neoplasm: The genome of the colon cancer cell line COLO-205 is highly methylated at site 2, and when the cells were treated with 5′AZA (inhibitor of DNA methylation), histone opening mark (histone 3 lysine acetylation) at the HNF-1 binding region of B3GALT5-LTR promoter is reduced [64].