TGFB1 and pancreatic adenocarcinoma: In fact, IL-10 acts as a mediator of the anti-inflammatory response and as an inhibitor of macrophages and dendritic cells (DCs) [23], and TGF-β is known to act as a pro-tumorigenic by induction of an epithelial-mesenchymal transition (EMT) in pancreatic adenocarcinoma [24].