In mice, HMGN1 was shown to bind to the promoters of the proto-oncogene FosB and Hmgn1−/− mice show upregulated expression of the proto-oncogenes FosB, C-fos, BclL3 and N-cadherin and downregulation of JunB, and c-Jun, suggesting a possible role of this HMGN variant in modulating the action of these factor during cancer development [57,58]. This evidence concerns the gene FOSB and cancer.