DSPP and dentinogenesis imperfecta type 3: The inverse case, i.e., a change from proline to leucine, has also been reported to affect protein secretion: a Pro->Leu mutation in the signal peptide of DSPP (Dentin Sialophosphoprotein) resulted in a defective secretion of this protein and was associated with dentinogenesis imperfecta type III in a Korean family [47].