CD274 and hereditary clear cell renal cell carcinoma: In 2016, a meta-analysis of 20 trials involving patients with melanoma, non-small cell lung cancer and renal cell carcinoma receiving anti-PD-1/PD-L1 antibodies showed that PD-L1 expression is significantly associated with risk of death and clinical response to anti-PD-1/PD-L1 ICIs in melanoma patients.