Based on the anti-inflammatory and antineoplastic properties found for conjugates of the n-3 long-chain PUFAs [28,29,30,31,33,34,40,41,42], we investigated the effects of two DHA metabolites, DHEA and DHA-5-HT, and the synthetic PPARγ ligand rosiglitazone (BRL-49653), on modulating TAM polarization induced by breast cancer cell conditioned media (BCC-CM). Here, PPARG is linked to breast carcinoma.