Patients with massive APE had a significantly lower albumin level [median (IQR): 2.8 (2.2, 3) vs. 3.2 (2.8, 3.6) gm/dL, P < 0.001) and higher RDW (median (IQR): 14.7 (13.8, 17.1) vs. 14.2 (13.3, 15.6), P = 0.006) compared with subjects with non-massive APE, respectively (Figure 1 panel a, b). The gene discussed is ALB; the disease is apparent mineralocorticoid excess.