The wide spectrum of the renal tumours with eosinophilic cells should all be considered in the differential diagnosis of ESC RCC, which includes primarily renal oncocytoma and the eosinophilic variant of chromophobe renal cell carcinoma (Chr RCC), as well as some less common entities, such as succinate dehydrogenase (SDH)-deficient RCC, MiTF translocation RCC (particularly TFEB), and epithelioid angiomyolipoma (AML), as shown in Table 2. This evidence concerns the gene TFEB and Renal neoplasm.