Prior psoriasis studies on markers of local inflammation which are associated with an increased risk of CVD include myeloperoxidase, a pro-inflammatory heme protein released by myeloid cells (most likely released into circulation by MPO-producing skin-infiltrating myeloid cells), and resistin, an adipose-tissue derived hormone (most likely from adipose tissue subjacent to psoriasis plaques) [21,22,23,24,25]. This evidence concerns the gene RETN and psoriasis.