VAPB and amyotrophic lateral sclerosis: Until now, VAPB aggregates have been characterized and described in VAPB-P56S cellular models [11,13,15,18,38] in spinal cord sections of transgenic mice carrying VAPB-P56S mutation [23] and in cutaneous fibroblasts [52] and postmortem spinal cord sections of ALS-8 patients [22,53].