VAPB and amyotrophic lateral sclerosis: Among ALS-causative genes, a point mutation, proline to serine substitution at position 56 (P56S), in a vesicle-associated membrane-protein-associated protein B (VAPB)-encoding gene, responsible for a rare fALS case and classified as ALS-8 [11], has been identified, which is associated with a highly variable clinical course [12].