Second generation checkpoint inhibitors, such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) inhibitors, have followed [6,7], and, today, more than 10 different immunotherapeutic agents, including checkpoint inhibitors, vaccine-based therapies, oncolytic viruses, and T-cell directed therapies for nearly 20 different indications across countless tumor types are available [1]. This evidence concerns the gene PDCD1 and neoplasm.