Intriguingly, the results not only showed that effective inhibition of both markers occurred with treatment but an important activation of the apoptosis program was also put in place accordingly, as demonstrated by the appearance of caspase 3 cleaved bands in GBM cells treated with crocetin, which was also described in human acute promyelocytic leukemia cells [32]. Here, CASP3 is linked to acute promyelocytic leukemia.