For example, in the mid-1990s, the transmembrane regulator of cystic fibrosis was introduced into the respiratory epithelium of patients with cystic fibrosis [120], dystrophin into the muscle cells of patients with Duchenne myodystrophy [121], and low-density lipoprotein receptor into the liver of patients with familial hypercholesterolemia [122]. The gene discussed is VLDLR; the disease is cystic fibrosis.