Multiple observations have evidenced that cortactin expression is increased in various types of human cancers, including gastric cancer, colorectal carcinoma, pancreatic cancer, head and neck squamous carcinomas (HNSCC), hepatocellular cancer, breast cancer and ovarian cancers [39,63,64,65,66,67,68]. The gene discussed is CTTN; the disease is head and neck squamous cell carcinoma.