Several distinct mechanisms are involved in their anticarcinogenic effect in breast cancer: interference with redox balance, pro-apoptotic effect, cell cycle arrest, activation of autophagy, inhibition of angiogenesis, anti-inflammatory effect, anti-estrogenic effect, changes in ER expression, aromatase modulation, interference with HER2 signaling, and effect on microbiota [131,132]. Here, ESR1 is linked to breast carcinoma.