Green tea polyphenols (EGCG) associated with quercetin enhanced the therapeutic effect of docetaxel in metastatic and castration-resistant prostate cancer through downregulation of MRP expression, decreased percentage of CD44+/CD24− stem-like cells and induced inhibition of PI3K/AKT/STAT3 signaling pathway [204]. This evidence concerns the gene AKT1 and Familial prostate cancer.