BCL2 and colorectal cancer: In vivo studies have shown that curcumin sensitizes human colorectal cancer to capecitabine in an orthotopic mouse model, through inhibition of NF-κB, decreased expression of genes enconding for proteins involved in proliferation (COX-2), invasion (MMP-2, ICAM-1), metastasis (CXCR4), angiogenesis (VEGF) and anti-apoptotic gene products (Bcl-2, IAP-1 and survivin) [269].