POMC and chronic kidney disease: Following multivariable analysis, the significant clinical predictive factors used in the stimulation tests for AI clustered by ACTH dose were CKD (RR = 2.52, p < 0.001), Cushingoid appearance in those with exogenous steroid and/or herbal medicine ingestion (RR = 3.44, p < 0.001), symptoms of nausea and/or vomiting (RR = 1.84, p = 0.003), and symptoms of fatigue (RR = 1.23, p < 0.001).