CRP and colorectal cancer: Furthermore, Otani et al. found that individuals in the highest quartile of CRP levels had a 1.6-fold (OR: 1.6; 95% CI: 1.1–2.5; p-trend = 0.053) greater risk of colorectal cancer compared with those in the lowest quartile [33], as supported also by a meta-analysis (1.12-fold increased risk per 1 unit change in natural log-transformed CRP levels) [34].