Some TYK2-dependent cytokines have a central role in tumor immunosurveillance (type I IFN, IL-12, see Figure 1), some are thought to be important based on assigned functions in immunity or inflammation (e.g., IL-23, IL-10, IL-22) and some are attracting attention for evolutionary reasons (e.g., IL-26, type III IFN; [113,114]). The gene discussed is IL10; the disease is neoplasm.