Interestingly, a neuronal-specific isoform of YAP, YAPdeltaC, protects against neuronal apoptosis in a model of the neurodegenerative disease Huntington’s disease (HD), by blocking interaction of full-length YAP with p73 [115], and was recently shown to modulate neurodegeneration in a mouse model of spinocerebellar ataxia 1 [116]. Here, YAP1 is linked to Huntington disease.