*Inactivates NF-κB localization by inhibiting glycogen synthase kinase 3 (GSK-3) which prevent colitis-induced colorectal cancer*Suppresses cellular proliferation and tumor growth*Induces colon cancer cell apoptosis*Anticancer activity against colorectal cancer through the modulation of epithelial growth factor receptor (EGFR)*Activates antioxidative transcriptor Nrf2. Here, NFE2L2 is linked to colitis.