*Reduces the risk of adenomatous polyps*Prevents colorectal cancer through miRNA modulation*Protects against Barrett’s esophagus*Induces apoptosis and cellular arrest*Induces detoxification enzymes*Cytoprotective effect through the induction of Nrf2*Scavenges against free radicals. Here, NFE2L2 is linked to esophageal adenocarcinoma.