AKT1 and herpes simplex infectious disease: The KEGG pathway terms showing the highest levels of significance were the herpes simplex infection term (ecb05168) with 18 enriched DEGs, the pathways in cancer term (ecb05200) with 127 enriched DEGs, and the PI3K-Akt signaling pathway term (ecb04151) with 106 enriched DEGs (Figure 5).