According to the set of traits—AUC > 0.8 (Table 2), the highest OR values and linear separability of the expression levels between metastatic and non-metastatic tumors (Table 3), four genes could be distinguished as the strongest candidates for ccRCC metastasis biomarkers—CA9, NDUFA4L2, BHLHE41, and EGLN3. For these genes, the sensitivity indicators were in the range of 79–97% and the specificity was in the range of 68–91% (Table 2). The gene discussed is COXFA4L2; the disease is nonpapillary renal cell carcinoma.