Ligand-independent PTK activation of ETV6-NTRK3 and TrkC in breast and colon cancer leads to constitutive activation of the Ras-MAP kinase (MAPK) mitogenic pathway and the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, as well as upregulation of cyclin D1 mediating cell survival [111,113], In addition, its activation by TrkC and ETV6-NTRK3 is mediated via activation of c-Src by using complex formation [130,131]. Here, NTRK3 is linked to colonic neoplasm.