NPM1 and acute myeloid leukemia: As a result of the mentioned associations between LDH level (≥600 IU/L), WBC count (≥10,000 cells/mm3), and presence of FLT3 and NPM1 mutations, as well as their impact on OS, AML patients with high LDH level and WBC count need to be promptly investigated for FLT3 and NPM1 mutations.