More recently, ramipril administered before, during, and after fractionated WB irradiation (cumulative dose of 40 Gy) prevented both radiation-induced cognitive impairment and increased microglial activation, despite reduced hippocampal neurogenesis in the context of pharmacologic blockade of angiotensin II-mediated inflammation [62], suggesting that both the radiation dosing scheme and the timing/dose of ramipril administration may modulate the effects of treatment. This evidence concerns the gene AGT and Cognitive impairment.