JUN and rheumatoid arthritis: As a unique compound in RJ, 10-HDA significantly inhibits the activities of matrix metalloproteinases (MMP-1, MMP-3), p38, and the c-Jun N-terminal kinases-activating protein-1 (JNK-AP-1) signaling pathway, which could serve as a protective tool against the therapy of rheumatoid arthritis [160].