IGHE and asthma: We enrolled in the first phase 120 patients with N-ERD, 180 with asthma, and 180 control subjects, the female gender prevailed in the three groups with a statistical difference between asthma vs. CG (p = 0.04); regarding the age of the patients, those in N-ERD and asthma groups were around the fourth decade of life and were older than CG (p < 0.001), the eosinophil counts were higher in N-ERD compared with asthma and control groups (p < 0.001), but serum IgE levels were higher in asthma patients vs. N-ERD and CG (p < 0.001 by each comparison).